B cell epitopes (determinates) are composed of hydrophilic amino acids on the surface of the antigen that are easily accessible to and recognized by B cell receptors (BCR) and antibody molecules. They are usually composed of three to five spatially contiguous, continuous or discontinuous amino acid residues. The former is called linear epitope or continuous epitope, the latter is formed after the folding of the peptide chain, called conformation epitope or discontinuous epitope.
BCEDB associated B cell epitopes with Spike protein mutations and lineages of COVID-19, so you can visit each other among them.
Coronavirus are systemically classified as Coronaviridae Coronavirus (Coronavirus). A variant of the coronavirus is the pathogen that causes SARS. Coronavirus was first isolated from chickens in 1937. The virus particles are 60-200nm in diameter, with an average diameter of 100nm. They are spherical or oval in shape and have pleomorphism. The virus has an envelope with spinous processes on the envelope. The whole virus is like the corona.
The Spike protein of the novel coronavirus spike protein has two subunits, S1 and S2, and the receptor binding site (RBD) is located on the S1 subunit. It forms the spike on the outer membrane surface of virion in the form of trimer, and its main function is to recognize host cell surface receptors and mediate the fusion with host cells.
Jing Zhang, Ph.D. Professor in Bioinformatics
Email: jz2716@buaa.edu.cn
Beijing Advanced Innovation Centre for Biomedical Engineering.
School of Engineering Medicine.
BeiHang University.
Chengzheng Tai
Email: taichz@163.com
Beijing Advanced Innovation Centre for Biomedical Engineering.
School of Engineering Medicine.
BeiHang University.
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