Glioblastoma (Cohort3) HLA-Gene Relation
Relationship between neoantigens' located genes and neoantigens' binding HLAs. The frequency of genes decreased from upper to bottom, and the frequency of HLA allele decreased from left to right. The left top corner shows the HLAs with top binding capacity to neoantigens for glioma.
Gene Mutation
The Circos displays the changes of nucleotide at mutated site included in the neoantigens. The arrow is the nucleotide before and after a mutation occurs. The thickness of the arrow is the number of neoantigens harboring this mutation.
Amino Acid Mutation
The Circos displays the changes of Amino Acid at mutated site included in the neoantigens. The arrow is the Amino Acid before and after a mutation occurs. The thickness of the arrow is the number of neoantigens harboring this mutation.
Each row shows information of a patient, including gene symbol, mutation information associated with the gene, the corresponding neoantigen information and the patient's survival category.
| Gene | Chr | Ref | Ref | Alt | MT Allele | MT Peptide | MT Score | MT Score Rank | WT Peptide | WT Score | WT Score Rank | Survival Time | Patients Number |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AIMP1 | 4 | 107268739 | G | T | HLA-B*35:01 | KIWEQIQPY | 341 | 24 | KIWEQIQPD | 34764.5 | 2 | NA | NA |
| AIMP1 | 4 | 107268739 | G | T | HLA-A*02:01 | YLHTNDECV | 70.2 | 84 | DLHTNDECV | 19581.7 | 9 | NA | NA |
| ARSA | 22 | 51065383 | G | A | HLA-C*05:01 | FVEAQPPWL | 241.1 | 50 | SVEAQPPWL | 2870.7 | 41 | NA | NA |
| ATP8A2 | 13 | 26133142 | C | T | HLA-A*01:01 | FSDKTGMLT | 171 | 68 | FSDKTGTLT | 677.7 | 76 | NA | NA |
| C9orf142 | 9 | 139887120 | A | G | HLA-C*16:01 | SACFTPDSL | 321.5 | 30 | STCFTPDSL | 877.6 | 67 | NA | NA |
| CACNA1I | 22 | 40069028 | C | T | HLA-B*57:01 | VALPINPTI | 396.9 | 16 | AALPINPTI | 512.7 | 96 | NA | NA |
| CACNA1I | 22 | 40069028 | C | T | HLA-A*02:01 | TLEEIEINV | 59.8 | 89 | TLEEIEINA | 1103.6 | 61 | NA | NA |
| CATSPERB | 14 | 92159552 | G | A | HLA-A*02:01 | LMNHFLVIL | 36.6 | 92 | LTNHFLVIL | 1720.4 | 49 | NA | NA |
| CATSPERB | 14 | 92159552 | G | A | HLA-B*15:01 | LMNHFLVIL | 302.4 | 37 | LTNHFLVIL | 3441.4 | 38 | NA | NA |
| CCDC178 | 18 | 30554620 | T | C | HLA-C*06:02 | MRTLWQEHF | 451 | 10 | MHTLWQEHF | 6225.5 | 28 | NA | NA |
| CCDC39 | 3 | 180372556 | C | A | HLA-C*06:02 | SRIQLNGEL | 491.6 | 1 | SRIQLKGEL | 674.1 | 77 | NA | NA |
| CCDC39 | 3 | 180372556 | C | A | HLA-C*07:02 | SRIQLNGEL | 382.2 | 18 | SRIQLKGEL | 530.2 | 93 | NA | NA |
| CDH7 | 18 | 63548045 | A | G | HLA-B*15:01 | ISSNSDQSY | 257.4 | 48 | ISSNSDQNY | 854.1 | 70 | NA | NA |
| CFAP43 | 10 | 105905271 | C | T | HLA-A*11:01 | MDILYKLFK | 302.7 | 36 | VDILYKLFK | 870.4 | 69 | NA | NA |
| CFAP43 | 10 | 105905271 | C | T | HLA-B*41:02 | HQMDILYKL | 106.7 | 78 | HQVDILYKL | 611 | 86 | NA | NA |
| CNTNAP5 | 2 | 125530544 | C | T | HLA-B*44:02 | REMSEEGHF | 191.3 | 63 | RETSEEGHF | 2195.5 | 47 | NA | NA |
| CNTNAP5 | 2 | 125232393 | C | G | HLA-A*11:01 | KNFHGCIEK | 204.3 | 57 | KNFHGCIEN | 28407.6 | 4 | NA | NA |
| DLX6 | 7 | 96635615 | A | G | HLA-A*01:01 | YSHRSLAAY | 312 | 33 | YNHRSLAAY | 5735.5 | 29 | NA | NA |
| DOK2 | 8 | 21768192 | G | A | HLA-C*06:02 | YRFLRRFGW | 206.5 | 56 | YRFLRRFGR | 5348.2 | 30 | NA | NA |
| DOK2 | 8 | 21768192 | G | A | HLA-C*07:02 | YRFLRRFGW | 192.4 | 60 | YRFLRRFGR | 2499.6 | 44 | NA | NA |
| DOK2 | 8 | 21768192 | G | A | HLA-A*03:01 | FLRRFGWDK | 192 | 61 | FLRRFGRDK | 503.3 | 97 | NA | NA |
| DSC3 | 18 | 28584113 | A | G | HLA-B*35:01 | LPFSVLLTL | 16.3 | 95 | LLFSVLLTL | 7802.6 | 27 | NA | NA |
| DSC3 | 18 | 28584113 | A | G | HLA-B*35:01 | ILLGIALPF | 454.4 | 8 | ILLGIALLF | 3998.7 | 34 | NA | NA |
| DSC3 | 18 | 28584113 | A | G | HLA-B*07:02 | LPFSVLLTL | 99.8 | 80 | LLFSVLLTL | 19194.3 | 10 | NA | NA |
| EBF1 | 5 | 158135118 | G | A | HLA-B*07:02 | LPSNCSSSL | 8.5 | 97 | LPSNCSSSS | 1515.2 | 50 | NA | NA |
| EBF1 | 5 | 158135118 | G | A | HLA-B*35:01 | LPSNCSSSL | 26.6 | 94 | LPSNCSSSS | 1147.2 | 59 | NA | NA |
| EBF3 | 10 | 131760481 | G | C | HLA-C*07:01 | VRREQDLYV | 344.4 | 23 | VRTEQDLYV | 802.7 | 71 | NA | NA |
| EMP3 | 19 | 48832677 | T | C | HLA-A*02:01 | LLMFQLYTM | 13.1 | 96 | LFMFQLYTM | 3732.7 | 37 | NA | NA |
| EMP3 | 19 | 48832677 | T | C | HLA-C*12:03 | LLMFQLYTM | 335.6 | 27 | LFMFQLYTM | 593.6 | 89 | NA | NA |
| EMP3 | 19 | 48832677 | T | C | HLA-B*08:01 | LLMFQLYTM | 75.5 | 83 | LFMFQLYTM | 612.5 | 85 | NA | NA |
| FAM214A | 15 | 52901967 | T | A | HLA-B*15:01 | IARIAQHLF | 340.2 | 25 | IARIAQHLI | 8471.9 | 26 | NA | NA |
| FANCA | 16 | 89874771 | G | A | HLA-A*02:01 | ELWKIQSFL | 276 | 44 | ELWKIQSSL | 1295.2 | 51 | NA | NA |
| FOCAD | 9 | 20885218 | C | T | HLA-C*15:05 | TSLAFVHEV | 281 | 42 | TSLALVHEV | 651.2 | 80 | NA | NA |
| FOCAD | 9 | 20885218 | C | T | HLA-C*15:05 | FVHEVHIQL | 170.7 | 69 | LVHEVHIQL | 525.1 | 95 | NA | NA |
| GANAB | 11 | 62406494 | C | T | HLA-B*55:02 | RPRYHVPDV | 259.5 | 47 | RPRYRVPDV | 597.9 | 87 | NA | NA |
| GHITM | 10 | 85909923 | T | G | HLA-B*57:01 | GGLSTVAMW | 156.4 | 70 | GGLSTVAMC | 29102.6 | 3 | NA | NA |
| GREB1L | 18 | 18963580 | G | A | HLA-B*35:02 | QPIFSQLYL | 309.7 | 34 | RPIFSQLYL | 1131.6 | 60 | NA | NA |
| GRIN1 | 9 | 140062232 | C | T | HLA-C*07:02 | WRKNLQQYY | 480.3 | 4 | WRKNLQQYH | 8844.2 | 25 | NA | NA |
| IFNLR1 | 1 | 24507335 | C | T | HLA-B*15:01 | LQAAPGRPH | 153.1 | 71 | LQAAPGRPR | 5263.2 | 31 | NA | NA |
| ITGB6 | 2 | 160958335 | G | A | HLA-A*24:02 | KWQTGTNLL | 241.4 | 49 | KWQTGTNPL | 1168.7 | 58 | NA | NA |
| KCNH4 | 17 | 40327691 | C | T | HLA-B*35:01 | APHSIGLHY | 111 | 76 | APRSIGLHY | 667 | 78 | NA | NA |
| LAMA3 | 18 | 21451536 | G | A | HLA-A*11:01 | LTLSEVGLK | 34 | 93 | LTLSEVGLE | 17806.2 | 12 | NA | NA |
| MAPK4 | 18 | 48256169 | C | T | HLA-B*40:02 | GDLNGACIL | 459.3 | 6 | GDLNGACIP | 15960.1 | 16 | NA | NA |
| MED12L | 3 | 151078384 | A | T | HLA-B*15:01 | HLRSKFGVL | 469.4 | 5 | HLRSKFGDL | 3156.5 | 39 | NA | NA |
| MRGPRX3 | 11 | 18159696 | C | T | HLA-B*35:02 | LPQETLELL | 181.1 | 66 | LPQETLELS | 12846.6 | 19 | NA | NA |
| MTOR | 1 | 11189847 | A | T | HLA-C*15:05 | YTVPAVQGI | 117.5 | 75 | YTVPAVQGF | 871.5 | 68 | NA | NA |
| N4BP2 | 4 | 40123917 | G | A | HLA-C*17:01 | SIDSGSLTV | 280.6 | 43 | GIDSGSLTV | 677.8 | 75 | NA | NA |
| NCAM1 | 11 | 113103440 | G | T | HLA-B*35:02 | TPSASYLEL | 103.5 | 79 | TPSASYLEV | 724.6 | 73 | NA | NA |
| NLRP8 | 19 | 56482056 | G | T | HLA-A*02:01 | MLSIENCNL | 219.3 | 55 | RLSIENCNL | 975.4 | 64 | NA | NA |
| NLRP8 | 19 | 56482056 | G | T | HLA-C*02:02 | YLSVAQLEM | 138.8 | 72 | YLSVAQLER | 9956.2 | 22 | NA | NA |
| NLRP8 | 19 | 56482056 | G | T | HLA-A*02:01 | YLSVAQLEM | 62.4 | 88 | YLSVAQLER | 13870 | 17 | NA | NA |
| NLRP8 | 19 | 56482056 | G | T | HLA-B*40:02 | LEMLSIENC | 359.5 | 22 | LERLSIENC | 1197 | 57 | NA | NA |
| OR13C5 | 9 | 107360834 | C | T | HLA-C*07:02 | IFYRVITPM | 435 | 12 | IFYRVMTPM | 635.9 | 82 | NA | NA |
| OR13C8 | 9 | 107331834 | C | T | HLA-C*07:01 | DRYVAICYL | 315.8 | 32 | DRYVAICYP | 21483.8 | 8 | NA | NA |
| OR13C8 | 9 | 107331834 | C | T | HLA-A*11:01 | YVAICYLLR | 376 | 20 | YVAICYPLR | 613.1 | 84 | NA | NA |
| OR4K5 | 14 | 20389481 | C | T | HLA-C*15:05 | AAMAKAFSM | 452.6 | 9 | AAMAKAFST | 9524.3 | 24 | NA | NA |
| OR52J3 | 11 | 5067927 | C | T | HLA-A*02:01 | TLWEPMFYF | 109.5 | 77 | TLREPMFYF | 2775.2 | 42 | NA | NA |
| PAPL | 19 | 39590908 | G | T | HLA-C*07:02 | RVWDRFMRL | 290 | 39 | RVGDRFMRL | 954.8 | 65 | NA | NA |
| PECR | 2 | 216916197 | C | A | HLA-A*02:01 | LALEWACSV | 172.4 | 67 | LALEWACSG | 25969.1 | 5 | NA | NA |
| PHF12 | 17 | 27246277 | G | C | HLA-B*35:01 | VAALIQCDY | 97.2 | 81 | VAPLIQCDY | 1254.5 | 55 | NA | NA |
| PIK3C2G | 12 | 18650563 | A | G | HLA-C*12:03 | IIFKAGDGL | 276 | 44 | IIFKAGDDL | 530.1 | 94 | NA | NA |
| PKD1L1 | 7 | 47968824 | G | A | HLA-A*02:01 | NMSEAMAVI | 181.8 | 65 | NMSEAMAVT | 1285.8 | 52 | NA | NA |
| PRAP1 | 10 | 135165539 | C | G | HLA-B*40:02 | AEKDDQLVV | 187.7 | 64 | PEKDDQLVV | 10916.5 | 21 | NA | NA |
| PRSS23 | 11 | 86518986 | G | A | HLA-C*06:02 | SRTETQMGI | 490.3 | 2 | SRTETQVGI | 1209.2 | 56 | NA | NA |
| PRX | 19 | 40901443 | G | A | HLA-C*07:02 | FSLPKFGLL | 290 | 39 | FSLPKFGLS | 13798.6 | 18 | NA | NA |
| PRX | 19 | 40901443 | G | A | HLA-A*02:01 | LLGPKVAKA | 202.2 | 58 | LSGPKVAKA | 18683.5 | 11 | NA | NA |
| PVRL4 | 1 | 161049501 | G | T | HLA-B*07:02 | KPLDGSVLL | 81.8 | 82 | NPLDGSVLL | 651 | 81 | NA | NA |
| RNASEH2A | 19 | 12923985 | G | T | HLA-A*68:01 | RTAHTILEK | 338.3 | 26 | RTAQTILEK | 530.7 | 92 | NA | NA |
| RNPEP | 1 | 201966530 | T | C | HLA-B*07:02 | LPAGDRSLA | 271 | 46 | LLAGDRSLA | 16119.4 | 15 | NA | NA |
| RUNX3 | 1 | 25228923 | G | A | HLA-C*06:02 | HTYLPPPYL | 454.9 | 7 | HTYLPPPYP | 22251.1 | 7 | NA | NA |
| RUNX3 | 1 | 25228923 | G | A | HLA-C*07:02 | HTYLPPPYL | 316.7 | 31 | HTYLPPPYP | 23440.3 | 6 | NA | NA |
| SIGLEC6 | 19 | 52033032 | G | A | HLA-A*02:01 | FTCCAQHPL | 281.6 | 41 | FTCRAQHPL | 1281.3 | 53 | NA | NA |
| SLC6A1 | 3 | 11067190 | G | A | HLA-B*15:01 | ILFFHGVTL | 301.5 | 38 | ILFFRGVTL | 654.5 | 79 | NA | NA |
| ST3GAL6 | 3 | 98489745 | C | T | HLA-B*40:02 | VEMKWRNKI | 67.5 | 85 | VEMKRRNKI | 545.8 | 90 | NA | NA |
| SYT6 | 1 | 114680617 | C | G | HLA-A*33:01 | MHVSSVDYR | 385.1 | 17 | MHVSSVDYG | 35595 | 1 | NA | NA |
| TCTN1 | 12 | 111078270 | C | T | HLA-B*15:01 | LTLVNAGHF | 191.5 | 62 | PTLVNAGHF | 9648.6 | 23 | NA | NA |
| TIMM44 | 19 | 7997767 | G | A | HLA-C*07:02 | AFIWASRAL | 420.1 | 15 | AFIRASRAL | 597.4 | 88 | NA | NA |
| TIMM44 | 19 | 7997767 | G | A | HLA-A*02:01 | FIWASRALT | 444.9 | 11 | FIRASRALT | 17409.4 | 13 | NA | NA |
| TIMM44 | 19 | 7997767 | G | A | HLA-B*18:01 | DESDNAFIW | 226.2 | 53 | DESDNAFIR | 2244.8 | 46 | NA | NA |
| TOP1 | 20 | 39751884 | C | T | HLA-A*24:02 | QWEKFAWAI | 305.5 | 35 | QREKFAWAI | 17284.4 | 14 | NA | NA |
| TREX2 | X | 152710600 | C | T | HLA-B*08:01 | GAMVRTLQA | 435 | 12 | GAVVRTLQA | 4870.5 | 32 | NA | NA |
| TREX2 | X | 152710600 | C | T | HLA-B*08:01 | MVRTLQAFL | 332.8 | 28 | VVRTLQAFL | 2618.2 | 43 | NA | NA |
| TRIM37 | 17 | 57078995 | C | T | HLA-B*15:01 | SVGGFHNSF | 223.9 | 54 | SVGGFHDSF | 696.2 | 74 | NA | NA |
| UNC45B | 17 | 33477238 | A | G | HLA-B*15:01 | IQGKLRVQF | 138.1 | 73 | IQEKLRVQF | 540.4 | 91 | NA | NA |
| UNC45B | 17 | 33477238 | A | G | HLA-A*33:01 | NTSIQGKLR | 420.8 | 14 | NTSIQEKLR | 626 | 83 | NA | NA |
| USP34 | 2 | 61441376 | A | G | HLA-B*40:02 | KNIAFNYTL | 485.3 | 3 | KNIAFNYIL | 888.4 | 66 | NA | NA |
| USP34 | 2 | 61441376 | A | G | HLA-C*16:01 | KNIAFNYTL | 378.9 | 19 | KNIAFNYIL | 1091.3 | 62 | NA | NA |
| VSIG4 | X | 65247336 | T | G | HLA-B*35:01 | WPTDMDGYL | 64 | 87 | WTTDMDGYL | 3873.3 | 36 | NA | NA |
| WNK3 | X | 54280398 | G | T | HLA-B*40:02 | AEYMVEDNF | 193.3 | 59 | ADYMVEDNF | 3115.3 | 40 | NA | NA |
| WNK3 | X | 54280398 | G | T | HLA-B*44:03 | AEYMVEDNF | 67 | 86 | ADYMVEDNF | 4676.9 | 33 | NA | NA |
| XRN2 | 20 | 21346120 | G | A | HLA-C*15:05 | RARKPAAVL | 229.7 | 52 | GARKPAAVL | 1884.7 | 48 | NA | NA |
| ZC3H11A | 1 | 203819154 | G | A | HLA-A*11:01 | KTKPKVNVK | 240.6 | 51 | KAKPKVNVK | 1260.8 | 54 | NA | NA |
| ZFHX2 | 14 | 23995127 | G | A | HLA-B*35:02 | SPVLPPFPL | 137.2 | 74 | PPVLPPFPL | 3880.6 | 35 | NA | NA |
| ZFHX2 | 14 | 23995127 | G | A | HLA-B*35:02 | APLFTSPVL | 372.9 | 21 | APLFTPPVL | 784.5 | 72 | NA | NA |
| ZFHX2 | 14 | 23995127 | G | A | HLA-C*15:05 | FTSPVLPPF | 325.5 | 29 | FTPPVLPPF | 1043.2 | 63 | NA | NA |
| ZNF365 | 10 | 64382999 | C | T | HLA-C*03:04 | LGNPWTSSM | 50.4 | 90 | LGNPWTSST | 10927.5 | 20 | NA | NA |
| ZYG11A | 1 | 53333251 | C | T | HLA-A*26:01 | FVMRWLCKY | 45.4 | 91 | FVMRWLCKH | 2491.2 | 45 | NA | NA |